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All research involving human subjects that is conducted at or sponsored by the University of Illinois at Urbana-Champaign, whether funded or unfunded, and whether conducted by Illinois faculty or others, must comply with applicable policies for the protection of human subjects. Under a formal assurance made by the campus and approved by the federal Office for Human Research Protections (OHRP), and per federal regulations, the Institutional Review Board (IRB) is given broad authority and wide-ranging responsibilities for ensuring the ethical and legal conduct of human subject research at Illinois.

  • Research funded or supported by the Department of Defense (DoD) must be reviewed by the IRB under an additional set of federal regulations [32CFR219]. The DoD follows the DHHS and FDA regulations on human subjects research, but also applies DoD regulations for protection of human subjects at 32 CFR 219 and DoD Instruction 3216.02 "Protection of Human Subjects and Adherence to Ethical Standards in DoD-Supported Research."

  • OPRS and the IRBs follow the Policy and Procedure Manual when reviewing new and ongoing research. The Policy and Procedure Manual is available for review by the research community. Please note the current manual is being revised in light of changes to federal and international regulations and a new version will be made available when complete.

  • Box is now available for storing Protected Health Information. Individuals who would like to use Box to store PHI, may only do so in a provided Box Health Data Folder. A request for a Box Health Data Folder can be submitted here. Researchers are responsible for following set policies and guidance listed at the previous webpage.

  • Regulations require IRBs and PIs to retain research data while the resesearch is being conducted and after the research is completed. As a result, researchers must comply with the longest applicable standard according to current state and institutional policies. 

  • The Biomedical Imaging Center (BIC) at the Beckman Institute is a state-of-the-art biomedical imaging facility that researchers on campus can utilize.

  • Effective January 17, 2017, OPRS will implement procedures for granting IRB approval, for eligible protocols, for an extended period of three years.

  • A registry and results database of federally and privately supported clinical trials conducted in the United States and around the world. is a service of the U.S. National Institutes of Health and provides information about a trial's purpose, who may participate, locations, and phone numbers for more details.

  • The Family Educational Rights and Privacy Act (FERPA) is a Federal law that protects the privacy of student education records. The law applies to all schools that receive funds under an applicable program of the U.S. Department of Education.

  • The Office for Human Research Protections (OHRP) provides leadership in the protection of the rights, welfare, and wellbeing of subjects involved in research conducted or supported by HHS. OHRP has published a variety of policy and regulatory guidance materials to assist the research community in conducting ethical research that is in compliance with the HHS regulations.

  • The Health Insurance Portability and Accountability Act (HIPAA) Privacy Rule protects personal health information and gives patients a variety of rights. The HIPAA Privacy Rule establishes the conditions under which protected health information may be used or disclosed by covered entities for research purposes.

  • The Food and Drug Administration (FDA) is an HHS agency that regulates clinical investigations of products under its jurisdiction, such as drugs, biological products, and medical devices. FDA regulations are published as part of chapter 21 of the CFR, and FDA's human subject protection regulations are in parts 50, 56, 312 and 812.

  • The U.S. Department of Health and Human Services (HHS) issues and enforces rules pertaining to the protection of human subjects in research. All regulations issued by federal agencies under the statutory authority established by Congress are published in the Code of Federal Regulations (CFR). Regulations pertaining to the protection of humans subjects can be found in Title 45 Part 46 (45 CFR 46) and is divided into four subparts: A, B, C, and D.

  • The act requires informed consent documentation for College of Medicine research to be provided in a language that is understandable to the research subject/participant.

  • The act provides that information derived from genetic testing is confidential. It limits the use of genetic information by insurers and employers and provides an exception to the confidentiality of genetic information with respect to criminal proceedings.

  • While any person may make a report if they have reasonable cause to believe that a child or elder was abused or neglected, Illinois Public Act Code mandates that personnel of higher education institutions who suspect child or elder abuse or neglect report this to the Illinois Department of Children and Family Services (DCFS) or the Illinois Department on Aging, as appropriate.

  • The general statement of policy outlines the University of Illinois at Urbana-Champaign's basic responsibility to ensure the protection of human subjects and is applicable to all research involving human subjects.

  • On an annual basis, the University will perform a review of the human research protections program. The OPRS staff will conduct audits of ongoing research when directed by the IRB for reasons such as complaints or allegations of non-compliance. 

  • Research activities that are designed as part of a course requirement for purposes of learning experience only and are NOT designed to develop or contribute to generalizable knowledge MAY not require IRB review and approval. 

  • Recruitment of students from courses taught by the investigator may raise special ethical concerns. The primary issue with gathering data from one's own course is the potential for perceived coercion. 

  • There are ethical guidelines that govern all research involving student subjects. Campus policy governs the use of students in research and are intended to assist researchers in understanding and applying those campus policies. 

  • In an effort to reduce survey fatigue all surveys, studies, assessments, evaluations, or research involving University of Illinois students is to be registered with the Office of the Dean of Students through the Student Affairs Research Approval (SARA) process. This process is overseen by Dr. Belinda De La Rosa and approved by the Dean of Students, Kenneth T. Ballom.

  • University students and employees may volunteer or be recruited as potential subjects; however, additional safeguards are required for these subjects.

  • The Office of Business and Financial Services provides guidance and procedures for making payments to human subjects for their participation in a research project or program. 

    Compensating Human Participants FAQs

  • Health and Human Services (HHS) requires additional financial disclosure and training for anyone involved in the design, conduct and analysis of PHS-funded research, including PIs, co-PIs, academic professional research staff, postdoctoral research associates, and graduate research assistants.

  • Campus Administrative Manual: The policy describes the role of the Institutional Review Boards and the responsibilities of the investigators engaged in university-sponsored research activities involving human subjects, human tissues, or medical records of human subjects.

  • Campus Administrative Manual: This policy establishes the role and responsibilities of a Principal Investigator; the categories of appointments for those individuals who are eligible to serve as a Principal Investigator; and an approval procedure to allow those individuals who are not included in the default categories to serve as Principal Investigators.

  • University Office of Human Resources and University Ethics Office: This policy outlines general requirements and safeguards the University has adopted with the intention to better protect minor children when they are on University premises participating in University programs and activities designed to include minors, or when they are in the care of University staff.

  • Office of the Vice President for Academic Affairs: The external activities of University employees can lead to conflicts of commitment or interest with regard to one's university responsibilities. This policy provides a general framework against which the propriety and advisability of non-university activities can be measured and monitored.

  • Full disk encryption (FDE) helps prevent unauthorized access to data stored on a device if that device is lost or stolen. As of January 1, 2013 all University owned laptops must be encrypted with FDE, per the laptop standard.