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Revisions to the Common Rule

The federal regulations that govern human subjects research, the Common Rule (45 CFR 46), have been revised. The revisions went into place January 21, 2019. Read about the changes and how OPRS is implementing them here.

What's Happening

Upcoming Meetings

July 9, 2019

Next Social Behavioral IRB meeting

July 11, 2019

Next Biomedical IRB meeting

See all meeting dates

Agenda Items

Submissions are pre-reviewed by OPRS before IRB review. Items requiring full board review must be determined to be ready, with pre-review issues resolved, no less than two weeks prior to the meeting date. This allows adequate processing time and ensures sufficient review time for the IRB members.

OPRS Office Hours - now available!

Dear research community, the OPRS is excited to announce that we will now be offering walk-in office hours. This is your opportunity to stop by our office and ask OPRS staff reviewers questions related to your IRB protocol or the UIUC IRB process. No appointment needed. See below for upcoming dates and times.


July 12, 2019 [10am-12pm]

August 9, 2019 [10am-12pm]

September 13, 2019 [10am-12pm]

Forms Revised

On December 3, new versions of our Protocol and Exempt Forms were updated to be compliant with the revisions to the Common Rule. Beginning January 9, 2019, current versions of the Protocol and Exempt Forms (version dated, 12/03/2018) will be required for all new submissions. New submissions on previous versions of the Protocol or Exempt Forms will be returned to the PI with instructions to resubmit on current forms. All applications must be type written and signed by the PI. New forms can be accessed here.

Smart IRB

Illinois is now a member of SmartIRB, an online reliance system to aid in collaborative agreements across campuses.

Research in the News

Check out various news items related to human subjects research here.

Graphic that displays the OPRS workflow

What is the OPRS?

The Office for the Protection of Research Subjects (OPRS), while performing administrative functions of the Institutional Review Board (IRB), serves as the official oversight office for human subject research at Illinois. The office is the central point of contact for investigators, research subjects, and regulatory agencies. OPRS organizes and documents the IRB review process, monitors research regulations, produces educational resources for faculty and staff, and provides assurance that the Urbana campus is in compliance with federal, state, and campus policies. Contact OPRS.

About the IRB

All research involving human subjects that is conducted at or sponsored by the University of Illinois at Urbana-Champaign, whether funded or unfunded and whether conducted by Illinois faculty or others, must comply with applicable policies for the protection of human subjects.


Federalwide Assurance #00008584

Expires: 10/18/2022