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COVID-19: The University of Illinois at Urbana-Champaign (‘Illinois’) Office for the Protection of Research Subjects (‘OPRS’) continues to develop plans to both protect the safety and health of our community as well as to ensure continuity of our business operations. Please see information and guidance for researchers here.

What's Happening

Upcoming Meetings

May 25, 2021

Next Social Behavioral IRB meeting

May 13, 2021

Next Biomedical IRB meeting

See all meeting dates

Agenda Items

Submissions are pre-reviewed by OPRS before IRB review. Items requiring full board review must be determined to be ready, with pre-review issues resolved, no less than two weeks prior to the meeting date. This allows adequate processing time and ensures sufficient review time for the IRB members.

Education & Outreach Update

In-person OPRS presentations are on hold until further notice. If you have a request for a Zoom presentation, please provide OPRS with more information by emailing

Smart IRB

Illinois is now a member of SmartIRB, an online reliance system to aid in collaborative agreements across campuses.

Research in the News

Check out various news items related to human subjects research here.

Graphic that displays the OPRS workflow

What is the OPRS?

The Office for the Protection of Research Subjects (OPRS), while performing administrative functions of the Institutional Review Board (IRB), serves as the official oversight office for human subject research at Illinois. The office is the central point of contact for investigators, research subjects, and regulatory agencies. OPRS organizes and documents the IRB review process, monitors research regulations, produces educational resources for faculty and staff, and provides assurance that the Urbana campus is in compliance with federal, state, and campus policies. Contact OPRS.

About the IRB

All research involving human subjects that is conducted at or sponsored by the University of Illinois at Urbana-Champaign, whether funded or unfunded and whether conducted by Illinois faculty or others, must comply with applicable policies for the protection of human subjects.


Federalwide Assurance #00008584

Expires: 10/18/2022